Top bowler Kagiso Rabada will be rested for the series, along with Lungi Ngidi, as South Africa look ahead to the two-Test series against Sri Lanka, which begins later in November.
Six uncapped players named in South Africa ODI squad
Rishabh Pant's return to competitive cricket after a three-month injury-enforced hiatus will be the primary focal point of India A's four-day match against South Africa A.
India A skipper Rishabh Pant will look to build on the gains from the first match, while the likes of Mohammed Siraj and Kuldeep Yadav will aim for crucial red-ball game time in the second four-day match against a Temba Bavuma-led South Africa A in Bengaluru from Thursday.
South Africa named uncapped Neil Brand as their captain for a two-match Test tour of New Zealand next month where the majority of their team will be missing, competing instead in the domestic Twenty20 league.
India's solitary ODI series win in the Rainbow nation occurred in 2018, emphasising the need for a strong beginning from Ruturaj Gaikwad and B Sai Sudharsan.
Sanju Samson will look to continue his domination of the bowlers but India need more stability in the top order
Captaon Suryakumar Yadav, all-rounders Hardik Pandya and Axar Patel, the only member from the Test side, will be hoping for a strong outing so that India can apply some balm over the wounds from their recent home series defeat against New Zealand.
India have used 12 out of their 15 players in the first three games and it would be interesting to see if one among the two uncapped pacers Yash Dayal or Vysakh Vijaykumar gets a debut cap in case the pitch warrants an extra specialist speedster.
South Africa have rested batter Temba Bavuma for their home white-ball series against India this month after a poor Cricket World Cup, but he will captain the team in the two-Test series which starts on Dec. 26.
Patidar or Rinku set for debut; India look to seal series
India's journey into their ODI future will hit its first stop during the opening match against South Africa on Sunday.